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What is an alteration?

What is an alteration? Here are some definitions.

Noun
  1. The act of altering or making different.
  2. The state of being altered; a change made in the form or nature of a thing; changed condition.
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Important mechanisms for epigenetic alteration of gene expression include DNA methylation and histone acetylation.
The alteration to or imitation of older styles was not limited to the 19th century.
The scale of alteration can vary in extent from less than a centimetre to many tens of kilometres.
The only major alteration was with the windchests, where the bottom boards were replaced with plywood.
It is an alteration product of realgar, native arsenic, and, less commonly, arsenopyrite.
From the 1940s to the 1970s, different techniques in keratomileusis evolved in surgical alteration of the cornea.

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