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What does exasperation mean?

Looking for the meaning or definition of the word exasperation? Here's what it means.

Noun
  1. The act of exasperating or the state of being exasperated; irritation; keen or bitter anger.
  2. Increase of violence or malignity; aggravation; exacerbation.
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Examples
Despite the exclamation mark, he talks in the flat, imperturbable vowels of Sussex, his voice rising not so much in volume as in exasperation.
In exasperation, Hoxsey attempted an end run by approaching the National Cancer Institute.
The brown-haired boy mussed his hair in exasperation, growling in his frustration.
The doctor tried to reason with me but finally gave up with a look of exasperation.
A loud squawk startled her, and she looked up to find the gull hanging over the drop-off and glaring at her in what looked like exasperation.
There was also a half hour of exasperation when I temporarily mislaid my handheld somewhere in the hospital.

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