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What are megrims?

What are megrims? Here are some definitions.

Noun
  1. plural of megrim
  2. Any of various diseases of animals, especially horses. (More at megrim.)
  3. (usually with "the") Depression, low spirits, unhappiness.
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Examples
This was the first attack of the megrims that I remembered in my mistress since the time when she was a young girl.
Have you no arts of the toilet that can overcome the story of your megrims?
I want you to tool her through to-morrow, and get over your megrims first.
Remember how you made me shake off the megrims by exertion in Philadelphia?
Fait then, your honour, my master's in bed with a terrible fit of the megrims.
She had sickened him by her megrims, as Tracy had prophesied she would!

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